New Jersey Senator Bob Menendez and his wife have been indicted on bribery charges.

Federal prosecutors announced the charges against the 69-year-old Democrat on Friday, nearly six years after an earlier criminal case against him ended with a deadlocked jury. The latest indictment is not related to the previous charges, which alleged Menendez accepted lavish gifts to pressure government officials on behalf of a Florida doctor.

The Senate Historical Office says Menendez appears to be the first sitting senator in U.S. history to be indicted on two unrelated criminal charges.

Attorneys for Menendez and his wife did not respond to messages seeking comment.

In his first indictment, Menendez was accused of using his political influence to help a Florida ophthalmologist who gave him gifts and campaign contributions.

The new indictment follows a years-long investigation that, among other things, examined the dealings of a New Jersey businessman, a friend of Menendez’s wife, who received exclusive permission from the Egyptian government to confirm that meat imported into that country complies with the Islamic dietary requirements. Investigators also asked questions about the Menendez family’s interactions with a New Jersey developer.

Menendez is up for re-election next year in a bid to extend his 30-year career in Washington, with Democrats currently holding a narrow majority in the Senate.